Pathophysiology of dental caries conrads g about i carious lesion dynamics are dependent predominantly on the availability of fermentable sugars other environmental conditions bacteria and host factors our current understanding of the microorganisms involved in the initiation and progression of caries is still rather incomplete. Pathophysiology of dental caries and metabolic alterations several hundred species of bacteria are resident in the oral cavity 8 of these 30 50 are regarded as cariogenic the mutans streptococci have received most attention in this respect cariogenic bacteria form a biofilm dental plaque in the deeper fissures of molar teeth around . Dental caries dental caries is an irreversiblemicrobial disease of the calcifiedtissues of the teeth characterizedby de mineralisation of inorganicportion and destruction of organicsubstance of the tooth which oftenleads to cavitationshafers textbook of oral pathology 6th edition 4. Dentinal caries dentine can be affected both pre cavitation and post cavitation of the lesion unlike enamel the presence of alive odontoblasts allows for reparative and protective changes to occurdue to lateral spread at the adj a larger cavity can form very quickly particularly larger than the apparent enamel lesion. Pathology focal enamel and dentin demineralization result in cavity formation there are multiple theories for their pathogenesis but contributing factors include a combination of a sugar rich diet anatomy oral cavity microbiome poor dental hygiene hyposalivation and time 12 dental caries are often categorized into 1
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